Coke oven workers have long-term been exposed to coke oven emissions (COEs). PAHs are important components of COEs that caused most seriously health effects among coke oven workers. Long-term exposure to PAH concentrations has been associated with lung cancer, respiratory cancer, urinary system cancer, skin cancer, and neurological diseases. This study conducted a cross-sectional epidemiology research for coke oven workers in a steel company in Taiwan. Based on job titles obtained from responses to the questionnaire survey, the coke oven workers were classified into two groups, including topside-oven workers (high exposure group, N=110), and side-oven workers (low exposure group, N=182). We quantified human subject exposure to 16 PAHs by using personal dosimetry. Urinary 1-hydroxypyrene (1-OHP) was used as an internal dose of exposure to PAHs, and urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG) was used as an oxidative DNA damage marker. The relationship between workers’ 8-OHdG and 1-OHP levels was estimated using linear mixedeffects models. Airborne PAHs levels in topside-oven workers significantly exceeded those in sideoven workers. The topside-oven workers’ geometric mean levels of urinary 8-OHdGand 1-OHP were significantly higher than those of side-oven workers, respectively. Urinary 1-OHP level, and work in topside-oven, gender were two significant predictors of urinary 8-OHdG levels, after adjustments are made for covariates. Oxidative DNA damage was associated with exposure of coke oven workers to PAHs.